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Both compound classes are contraindicated in active malignancy by clinical convention, given IGF-1's mitogenic properties

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Reduces Signs of Aging: Smoothens fine lines and wrinkles for youthful-looking skin

TGF- signaling is a key driver of this metabolic shift, upregulating enzymes such as PHGDH, PSAT1, PSPH, and SHMT1/2 that are essential for serineglycine biosynthesis and collagen production [17, 18]

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