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This work was supported by Al-Zaytoonah University of Jordan research funds (2019-2020/23/06) and (2022-2023/17/48)

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Research shows that GLP-1 agonists like semaglutide activate receptor sites throughout the brain and pancreas, triggering cascades that stabilize leptin signaling, dampen cortisol stress responses, and restore insulin sensitivity in people with metabolic dysfunction