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The methodological quality of the included studies, as assessed through the Jadad and NewcastleOttawa scales, varied from moderate to high, while the GRADE assessment indicated moderate certainty of evidence for serum vitamin B12 increase and low certainty for homocysteine reduction

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Once vitamin B12 levels have stabilized , Vibe 1 mg tablets (equivalent to 1,000 g) can be used for long-term treatment of anemia caused by vitamin B12 deficiency (pernicious anemia)