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There are a lot of people out there that could probably lose weight without GLP-1 drugs if they just discipline themselves and exercise more, but there is a segment of the population that cannot lose weight, and my daughter Alexa unfortunately falls within that category, Rich said

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Tricyclic Antidepressants (TCAs) and Monoamine Oxidase Inhibitors (MAOIs), though less commonly used as first-line treatments due to their broader side effect profiles, remain effective for treatment-resistant cases and specific mood disorders

The observation was characteristically self-deprecating, but it missed something essential

You start low