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PIKFYVE-dependent regulation of MTORC1 and TFEB

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The proteins targeted by DPP-4 include: Glucagon Glucagon-like peptide-1 (GLP-1) Glucagon-like peptide-2 (GLP-2) Glucose-dependent insulinotropic polypeptide (GIP) Thus, by inhibiting DPP-4, scientists have been able to raise natural levels of proteins that are useful in diabetes, providing a powerful treatment for managing the condition

The limited treatment landscape has created significant interest in repurposing existing drugs, particularly glucagon-like peptide-1 (GLP-1) receptor agonists, which address multiple metabolic pathways implicated in fatty liver disease