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One animal study examined the alcoholic extract of the Premna integrifolia Linn plant

Biochimica et Biophysica Acta (BBA) 1842:12401247 Wong HS, Dighe PA, Mezera V, Monternier PA, Brand MD (2017) Production of superoxide and hydrogen peroxide from specific mitochondrial sites under different bioenergetic conditions

10.1155/2019/6392763 65 HuangY.HuC.YeH.LuoR.FuX.LiX.et al (2019)

As mentioned before, these other three ingredients were added to support the role of glutathione as a skin-lightening agent to yield a synergistic effect as a depigmenting agent, in absorption, and in capsule formulations

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