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Some users discuss other effects, but the well-documented action is on melanin production in the skin

Acrolein contributes to the development of diabetic nephropathy by promoting the accumulation of extracellular matrix, increasing the production of angiotensin II (Ang II), activating MAPK signaling pathways that phosphorylate JNK, ERK, or p38, increasing the expression of inflammatory cytokines such as IL-6, IL-1beta, IL-18, and TNF-alpha, and cleaving caspase 9, caspase 3, and PARP (119)

Anton SD, Lee SA, Donahoo WT, McLaren C, Manini T, Leeuwenburgh C, et al

Maybe they need higher dosing