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So far, there are no published randomized, controlled trials investigating pharmacological treatment options for fluid intake in primary polydipsia

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Autophagy in immunity and inflammation

Small molecules targeting JAK/STAT and PDE4 pathways such as tofacitinib and apremilast present oral alternatives, though often with reduced efficacy compared to biologics and notable side effects like gastrointestinal intolerance or lipid changes [99]

This sex-specific effect may be linked to differences in how males and females respond to semaglutide, including typically greater weight loss among females