Rapid intravenous infusion can precipitate hypotension, while electrolyte disturbances may occur with inappropriate dosing or prolonged use
doi: 10.1186/s12916-020-01604-y 41 UyogaSMachariaAWNdilaCMNyutuGShebeMAwuondoKOet al
Additionally, the study assessed weight and metabolic responses, finding that efinopegdutides tolerability was similar to that of semaglutide, although certain gastrointestinal side effects were more common
2, the NADPH homeostasis is mainly regulated by several metabolic pathways and enzymes including NAD kinase (NADK), the pentose phosphate pathway (PPP), the folate-mediated one-carbon metabolism, malic enzymes (ME), the nicotinamide nucleotide transhydrogenase (NNT), cytosolic or mitochondrial NADP-dependent isocitrate dehydrogenase (IDH1 and IDH2), the glutamine metabolism, and the fatty acid oxidation (FAO)
All references to published data, proposed mechanisms, or preclinical observations are included solely for scientific and educational discussion