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Meaningful weight changes typically occur over several months, with maximal benefits observed after sustained use combined with structured lifestyle support

The article dates the hormone's identification to 1987, when researchers were studying intestinal hormones and its role in post-meal glucose regulation, and dates the first synthetic GLP-1 receptor agonist, exenatide, to FDA approval for type 2 diabetes in 2005

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Depletion of butyrate-producing clostridia from the gut microbiota drives an aerobic luminal expansion of Salmonella

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