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The current literature and expert consensus suggest that while these medications can be transformative for clinical populations (diabetics/obese patients), they offer no magic pill for a fit athlete beyond possible weight reduction and that weight loss can come at the expense of performance-critical factors like decreased muscle mass and inadequate fuelling

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The goal shifts from introducing new physiological changes to sustaining the beneficial ones already underway, which is why many patients maintain their weight loss trajectory for months at a single dose level