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Semaglutide & Tirzepatide is most effective when combined with healthy lifestyle changes, including diet and exercise

Cardiovascular outcome trials have established benefits for specific agents: the LEADER trial for liraglutide, SUSTAIN-6 for injectable semaglutide, and REWIND for dulaglutide demonstrated reduced risk of major adverse cardiovascular events in patients with type 2 diabetes

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The one small observational study suggested modest additional benefit, but high-quality randomized trials are lacking