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Methionine is an essential amino acid involved in fat metabolism and liver function, helping prevent fat accumulation in the liver during caloric restriction

In about 1% of patients with deficiency, optic neuropathy

However, the largest Phase IIb trial involving 536 subjects failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading Metabolic Pharmaceuticals to terminate development in 2007

G., & Frye, R

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