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There's also emerging research linking it to inflammation in the pancreas and kidneys , which is something to keep an eye on

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Variants in genes like FTO rs9939609 and MC4R rs17782313 influence baseline hunger hormones, metabolic rate, and how your body distributes fat tissue

NICE guidance on obesity and weight management recognises that sustained weight loss of 10% or more can significantly reduce the risk of type 2 diabetes, cardiovascular disease, and musculoskeletal problems