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These may include: A vitamin B12 deficiency can also lead to pernicious anemia

doi: 10.1073/pnas.0806192105

A recent trial of vitamin E in Israel, for example, showed a marked reduction in coronary heart disease among people with type 2 diabetes who have a common genetic predisposition for greater oxidative stress

In addition, real-world data on cost-effectiveness and optimal treatment duration are limited

The cysteine modification is expected to trigger a conformational change of the Keap1 homodimer, which could dissociate the weak binding site, the DLG motif (latch), from the Keap1 DC domain, while the strong binding site, the ETGE motif (hinge), remains attached to the other Keap1 DC domain