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Chronic telogen effluvium, a condition where shedding persists for more than six months, can occur when the triggering stressor is ongoing, such as continuous aggressive weight loss, unresolved nutritional deficiencies, or untreated thyroid dysfunction

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In the canonical SMAD pathway, activated TR I phosphorylates receptor-regulated SMADs (R-SMADs), primarily SMAD2 and SMAD3