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Description

For the NAD+/sirtuin connection, see NAD+ and Sirtuins

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This triple-agonist approach creates metabolic effects that exceed what any single or dual-receptor compound achieves alone

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Beyond simple actin sequestration, Bock-Marquette and colleagues reported in Nature (2004) that T4 activates integrin-linked kinase and Akt, promoting cardiomyocyte and epicardial cell migration and survival in mouse cardiac injury models, which established a signalling role separate from cytoskeletal buffering

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