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The published human evidence is thin and does not yet confirm it: in a small controlled study of healthy elderly men with low baseline IGF-1, six weeks of nightly GHRH injections increased nocturnal growth hormone release and improved two of six muscle-strength measures, but produced no measurable change in weight, waist-to-hip ratio, or DEXA-assessed fat and muscle mass (7)

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Findings in context of the broader literature Our results are consistent overall with a post hoc analysis of pooled SUSTAIN and PIONEER data, which also showed that the effect of semaglutide vs comparators on MACE was largely consistent across different CV subgroups [35]

These include pancreatitis, gallbladder problems, bowel obstruction, vision problems, kidney injury, and severe allergic reactions

Switch to Evidence-Based Methods Talk to your doctor about safe, proven weight loss options, including real GLP-1 medications if appropriate