[DOI] [PMC free article] [PubMed] [Google Scholar] 60
Providers should use compounded GLP-1 drugs only when no FDA-approved option is available, and be aware that these products carry risks of fraud, mislabeling, and unverified safety or quality
however, its maximal efficacy matched that of pregabalin only at the most significant tested dose of 300 mg/kg (Figure 1B)
Nearly half of those on the highest dose achieved at least 30% weight loss, which is the sort of result more often associated with bariatric surgery than with medication
Nerve growth factor (NGF), released by osteoblasts, endothelial cells, and infiltrating immune cells, plays a key role in promoting this ectopic innervation, establishing a direct link between structural bone changes and pain signaling ( via its receptor DCC, has been shown to drive the sprouting of calcitonin gene-related peptide (CGRP)+ nociceptive fibers in the subchondral bone, thereby contributing directly to pain hypersensitivity associated with OA (Zhu et al., 2019)
