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This may explain why side effects are relatively rare compared to pharmaceutical approaches that introduce foreign signaling molecules

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Misra and Tyler, 1999)

Imbalances between glutamate and GABA, which are strongly implicated in neuropsychiatric disorders like MDD [77], can lead to excitotoxicity, whereby excessive glutamate activation of NMDARs and AMPARs triggers calcium overload, oxidative stress, and cell death [78]