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Important safety considerations include a boxed warning for medullary thyroid carcinoma (MTC) risk with most GLP-1 medications, which are contraindicated in patients with a personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
The appetite suppression these drugs create makes it difficult to eat enough protein to preserve muscle mass, and roughly 25% of weight lost on GLP-1 drugs comes from lean tissue on average, with some trials reporting up to 40%
It is used as supplementation to support healthy nerves and help relieve symptoms like tingling and numbness in hands & feet (caused due to B-vitamin deficiency)
The right dose within this range varies based on symptom severity and health conditions
Studies show people on weight loss medications often reduce their calorie intake by 1639%, which can also mean fewer essential nutrients
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