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pregnancy and breast feeding period

found significantly decreased expression of autophagy markers, including Beclin1 and LC3, and increased p62 expression in stromal vascular fraction cells isolated from the adipose tissue of older mice (20 months) compared to that of younger mice (46 months) [84]

It is not appropriate during pregnancy or breastfeeding, in active cancer, or in patients with severely uncontrolled metabolic disease without specialist coordination

Endogenous adipocyte apolipoprotein E is colocalized with caveolin at the adipocyte plasma membrane

By delivering vitamin B12 directly through the nasal mucosa, it ensures efficient absorption into the bloodstream, helping prevent complications like anemia and neurological disorders related to B12 deficiency