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257 Disruption of the colonic barrier is the most common pathological change in animal models of UC, and studies have shown that the SGLT2 inhibitor empagliflozin can significantly increase the expression of SIRT-1, suppress the levels of PI3K and AKT, and increase the levels of tight junction proteins (claudin-1 and occludin), thereby improving the integrity of the colonic barrier

Whilst timing of supplementation is less critical than consistency, factors such as formulation type, food intake, and underlying gastrointestinal health significantly influence absorption efficiency

If you find yourself consistently missing doses, it's a conversation worth having with your provider to find a better routine or strategy

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