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Dapagliflozin and metformin hydrochloride extended-release tablets may increase the risk of hypoglycemia when combined with insulin and/or an insulin secretagogue [see Adverse Reactions (6.1)]

Using a footstool to elevate the knees above the hips can help straighten the anorectal angle, reducing straining during defecation

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If irritation or rash occurs, discontinue use immediately and consult a doctor

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