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By use of GRK overexpression and knockdown methods in HEK293 cells, the same group recently reported DAMGO-induced phosphorylation of Thr370 and Ser375 is catalyzed by GRK2 and GRK3, but morphine-induced phosphorylation of Ser375 is predominantly mediated by GRK5 (Doll et al., 2012)

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Serious liver damage that can cause death, especially in children younger than 2 years old.The risk of getting this serious liver damage is more likely to happen within the first 6 months of treatment