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The enzyme aldose reductase which produces intermediate sorbitol is a NADPH requiring enzyme with a high Km for glucose [7], thus elevated intracellular glucose concentrations and an adequate supply of NADPH leads to a significant increase in the amount of sorbitol

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That does not prove semaglutide will reduce alcohol cravings for everyone, but it does help explain why researchers are interested in GLP-1 medications as potential tools for reward-driven behaviors