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The evidence-based starting dose of 0.25mg activates MC1R-mediated melanogenesis without oversaturating MC4R, allowing gradual receptor adaptation during titration

Sikirics group has conducted extensive animal toxicology studies demonstrating no observed adverse effects, even at high doses across multiple species

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Schiavi S, La Rosa P, Petrillo S, Carbone E, DAmico J, Piemonte F, et al