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Brain image data acquisition in humans All multimodal MRI and MRS data were collected using a 3.0 Tesla Philips MR scanner system (Philips Healthcare, Best, The Netherlands) equipped with a 32-channel head coil

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Prescribers should use their independent clinical judgment when determining appropriateness for individual patients.

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Oxygen consumption rate (OCR) of intact cells were determined using the XF Cell Mitochondrial Stress Test according to the manufacturers protocol