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Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus

SLs are thought to play a role in regulating root system architecture, especially in response to nutrient availability and environmental stresses 78

Future frameworks will likely need to incorporate guidance for engineered strains, synbiotics, microbial consortia, and microbiome-based therapeutics, extending the FAO/WHO principles to more complex products while maintaining their core focus on strain specificity, safety, and evidence-based health benefits (531)