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In the present study, dietary L-carnitine supplementation increased the protein content of the whole body in the feeding trial, and did not affect the mRNA expressions of genes associated with protein and amino acid catabolism

410,411 Remarkably, patients with HER2+ advanced breast cancer achieved a significantly longer PFS using trastuzumab deruxtecan (T-DXd) than T-DM1 in the DESTINY-Breast03 trial

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3.3.3 Effect of metformin on birth weight in offspring of patients with polycystic ovary syndrome The progression of the placenta and fetus necessitates a heightened oxygen demand and the presence of fully developed mitochondria in the later stages of pregnancy to facilitate the transportation of essential nutrients for fetal development (Joshi et al., 2022)

Besides, Conventional small-molecule agonists/antagonists often cause off-target effects due to the widespread expression of ORs in extrapulmonary tissues (e.g., heart and kidneys)