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doi: 10.2337/dc25-S002 11 HermanRJHayesMRAudrain-McGovernJAshareRLSchmidtHD

Third, the glucagon receptor activation increases energy expenditure through cellular thermogenesis

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GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) are the primary members ( -cell regeneration, inhibiting -cell apoptosis, and improving -cell function, thereby lowering blood glucose levels, with its effects being glucose concentration-dependent ( In recent years, research has discovered the potential effects of GLP-1 and its analogs on the nervous system, particularly in relation to the bloodbrain barrier (BBB)

constructed a novel GLP-1/fibroblast growth factor (FGF)-21 dual receptor agonist (GLP-1-Fc-FGF21 D1), which was evaluated in HFD ob/ob mice in comparison with either FGF-21 (c-FGF21 S1) or GLP-1RA (dulaglutide) monotherapy