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Sci Rep 9(1):18409 Sullivan LB, Martinez-Garcia E, Nguyen H et al (2013) The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling

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Hwang J, Likasitwatanakul P, Deshmukh SK, Wu S, Kwon JJ, Toye E, et al

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This results in sustained weight loss , with clinical studies showing that patients can lose 15-20% of their total body weight over time

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In agreement with these observations, an increase in the reduced form of plasma homocysteine associated with an elevation of the oxidation rate of homocysteine and cysteine (expressed as a decreased ratio of plasma reduced to total aminothiols) was reported in experimental hyperhomocysteinemia (Guttormsen et al, 1993

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