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Have severe or unstable medical conditions (e.g., uncontrolled diabetes, end-stage renal disease, significant heart or liver disease) without first consulting a physician

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There are plausible reasons explaining this discrepancy between FLINT and FLINT-J study

Human pharmacokinetics, tissue distribution, and counter-regulatory responses can differ substantially from animal predictions

AsA-GSH pathway in peroxisome Peroxisomes are single membrane-bound subcellular organelles being involved in production as well as the degradation of H 2 O 2 and are sites for photorespiration, fatty acid -oxidation, glyoxylate cycle and ureide metabolism (Corpas et al., 2001