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I know there are quite a few variables with oral bioavailability, but assuming taken fasted,

Most people barely feel it

Other orthobiologics such as stem cell therapy or PRP, even newly developed cell editing drugs like Invossa for knee osteoarthritis have robust safety data in humans and ongoing randomized controlled trials to determine their efficacy

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One of them is Timmermans, the ND in Arizona who focuses his practice on chronic pain, orthopedic medicine, and sports medicine