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These structures are only found on antimicrobial sulfonamides, and not on non-antimicrobial sulfonamides. This is good news

Studies suggest this may have a modest improvement on body weight, body mass index and fat mass, but appears to have little impact on our waist circumference or body fat percentage

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The only requirement is an assessment of renal function before initiating therapy, and periodical check-ups thereafter are recommended (Figure 3)