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If digestive side effects worsen, a slower dose increase may be considered under medical supervision

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Serious but less common side effects requiring immediate medical attention include: Pancreatitis severe, persistent abdominal pain, sometimes radiating to the back Gallbladder disease including cholelithiasis (gallstones) and cholecystitis (gallbladder inflammation) Dehydration which may lead to acute kidney injury in severe cases Diabetic retinopathy complications particularly in patients with pre-existing retinopathy experiencing rapid improvement in blood glucose control [1] [2] Severe allergic reactions though rare, these require immediate medical attention The SmPC also notes that tirzepatide may reduce the absorption of oral medications due to delayed gastric emptying

1 Comparison of NAFLD and MAFLD diagnostic criteria