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The FOX1 method was notably employed by Hull and colleagues and revealed a significant elevation in lipid hydroperoxide concentrations in the ELF of CF patients exhibiting inflammation, compared to both the control group and the CF group without inflammation

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Biomarkers of immune activation such as NK cell activity, CD8 + T cell infiltration, cytokine profiles (IL-12, IFN- and IL10), and Treg/MDSC ratios help identify populations of patients likely to benefit from immunomodulatory agents whereas circulating levels of polyphenols, isoflavones or glucosinolate metabolites serve as a marker for PK properties that can be utilized to optimize dosing and exposure (224)

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