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CrossRef Resistin as Modulator of Functional Activity of Phagocytes in Colostrum and Blood of Overweight and Obese Mothers Carla Roberta Silva Souza Antnio, Elisia Possidnea Pereira, Danielle Cristina Honorio Frana, Patricia Gelli Feres de Marchi, Emanuelle Carolina Honorio Frana, Anibal Monteiro de Magalhes Neto, Elton Brito Ribeiro, Danny Laura Gomes Fagundes-Triches, Biomedicines.2025
Inhibit osteoclast activation and differentiation, reduce bone resorption Block osteoclast differentiation signal RANKL/RANK/OPG pathway: AOD 9604 downregulates the expression of RANKL (a key factor in osteoclast differentiation) and upregulates the expression of OPG (a RANKL antagonist), reducing the RANKL/OPG ratio by 50-60% and blocking the differentiation of osteoclast precursors into mature osteoclasts
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