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It is essential to distinguish medically indicated B12 replacement therapy from commercially marketed wellness injections, as they serve fundamentally different purposes and are subject to different regulatory oversight

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EECs highly express chemosensory machinery compared to non-EEC intestinal epithelial cells, including nutrient-specific G protein-coupled receptors (GPCRs) and nutrient transporters, enabling them to sense and respond to the intestinal milieu 17

Page 146 and 147: Interagency Work Group on Pharmaceu Page 148 and 149: Fernndez I, Mosquera-Corral A, Ca Page 150 and 151: doi:10.2175/106143007X156781

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