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Aspirin, diclofenac, ibuprofen, paracetamol and celecoxib were given in dose regimens shown to induce gastric and small intestine ulcers, hepatotoxicity and encephalopathy (8-14), and their effects were timely investigated

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These medications were developed by the monoamine hypothesis, which may be attributed to a deficiency in monoamine neurotransmitters ( Figure 1 illustrates the efficacy of probiotics, particularly butyrate-producing bacteria, to alleviate the physiological causes of MDD while also structurally modulating the intestinal flora