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These patients often require therapeutic doses under medical supervision

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Nerve Healing Potential : Experimental data show possible support for nerve regeneration, which may relate to recovery from nerve-related injuries or trauma

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Some studies have shown that metformin can reduce the absorption of vitamin B12 in 30% of people with type 2 diabetes (Vitamin B12 deficiency in metformin-treated type-2 diabetes patients, prevalence and association with peripheral neuropathy)