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MDS-UPDRS Part IV in endpoints The meta-analysis revealed no significant difference in MDS-UPDRS Part IV for individuals treated with GLP-1 receptor agonists compared to those receiving placebo (MD = 0.30

Moreover, pyruvate dehydrogenase kinase 4 (PDK4), localized to the IMM, has been implicated in metabolic regulation of ferroptosis by inhibiting pyruvate oxidation and altering lipid metabolic pathways, thereby modulating lipid peroxidation-dependent ferroptotic vulnerability [91] (Fig