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Ask them to smoke outside, and avoid areas where people smoke

The number of permutations, 250,000, was chosen to give a high degree of certainty for the permutation p-value, specifically, a 99% confidence interval for the p-values would have a precision (half width) of approximately 0.001

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Extensive education in Reykjavik elementary schools about the harmfulness of smoking on health and prevention measures were initiated by the Reykjavik Cancer Society, with rapid effects