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Int J Epidemiol 2003;32:794-799

DNA adducts from NNK metabolism DNA pyridyloxobutyl adducts NNK metabolism through -methyl hydroxylation produces DNA pyridyloxobutyl adducts (Fig

Brain: Increased risk of stroke Teeth: yellow colour, decay, gum disease Mouth: bad breath, cancers of mouth, tongue and lips Throat: cancer Eyes: increased risk of cataracts Face: more wrinkles, acne Oesophagus: cancer Larynx: cancer Lungs: cancer, COPD (chronic bronchitis emphysema), asthma exacerbations Heart: increased risk of heart attack, heartburn Pancreas: cancer Arms: decreased blood flow Stomach: acid secretions, cancer, ulcers Kidney: cancer Reproductive organs: erectile dysfunction, cervical and uterine cancer, infertility, risks to unborn babies, miscarriage Bladder: cancer Blood: Cancer of the myeloid line of blood cells

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