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[00:10:34] You know, initially patients will come to you and they're expecting an operation because they have symptoms, they have a hernia

As a reactive a,b-unsaturated aldehyde, acrolein can exacerbate dyslipidemia that can lead to accelerated atherosclerosis, modify A-I protein in high-density lipoprotein (HDL) [33, 34] and catalytic neutrophil-mediated inflammation [35], and enhance platelet activation which contributes to an increased risk of thrombosis in animal models [36]

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Anything that stretches the inner part of the arteries starts the progression of arterial sclerosis [a hardening or narrowing of the arteries], he said