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The regions with the most considerable DALY rate reductions were Australia, high-income Asia, and Central Pacific Latin America, respectively (Figure 2D)

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However, treatment-related AEs were reported by 30 participants allocated to snus (19.0%) compared to 18 in the placebo group (11.2%, p = 0.06), but they were mostly classified as mild and did not result in discontinuation of study treatment

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