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Antacids Concurrent administration of antacids containing magnesium hydroxide or aluminum hydroxide may reduce the bioavailability of ciprofloxacin by as much as 90% [see Dosage and Administration (2.4) and Drug Interactions (7)]

In contrast, the heating of glycerin can lead to an increase in acrolein, another toxic contaminant (not reported in our experiments because of the liquid refill composition used with no or low glycerin content)

These two changes make a big difference in the taste

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A., Sainio, P