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However, the authors of the research published in BMC Public Health did not find that it changed smoking behavior during the short term period of the trial

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We found no association between tobacco use and atopic dermatitis in Korean adults

Considering the rate of MVP observed in our cEDS cohort and the knowledge that the mitral valve depends upon collagen for its tensile strength and that myxomatous MVP is characterized by disruption of the collagen layer with expansion of glycosaminoglycans within the middle layer of the valve [123], it is reasonable to consider MVP as a potential clue for cEDS, although the true clinical significance is so far unknown