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During this process, toxic proteins including but not limited to cytochrome c, apoptosis inducing factor (AIF), second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI (SMAC/DIABLO) activate caspase proteases in the cytoplasm leading to cell death (Galluzzi et al., In the absence of caspase activity, cell can still undergo death via necrosis or necroptosis

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