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Carvedilol treatment mitigated hepatic enzyme damage, restored oxidative balance, modulated inflammatory state, and regulated endothelial (eNOS) and inducible (iNOS) nitric oxide synthase expression ( 7 Conclusion and future perspectives Based on the review of the impact of -blockers on glucose metabolism, insulin sensitivity, oxidative stress and inflammation, several conclusions and future perspectives can be drawn

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In a recently published randomised trial of 886 subjects who were willing to quit smoking [100], the abstinence rate was found to be twice as high in the e-cigarette group than in the nicotine-replacement group (18.0% vs